Comparison of high sensitive c reactive protein levels between metabolically healthy and unhealthy obese

I Made Pande Dwipayana; I Made Siswadi Semadi; Ida Bagus Aditya Nugraha; Wira Gotera; Made Ratna Saraswati; Anak Agung Gede Budhiarta; Ketut Suastika

doi:10.36216/jpd.v8i1.235

Authors

I Made Pande Dwipayana Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
I Made Siswadi Semadi Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
Ida Bagus Aditya Nugraha Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
Wira Gotera Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
Made Ratna Saraswati Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
Anak Agung Gede Budhiarta Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
Ketut Suastika Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar

DOI:

https://doi.org/10.36216/jpd.v8i1.235

Keywords:

hs-CRP, MHO, MUHO

Abstract

Introduction: Overweight and obesity are associated with risks of several comorbidities, yet not all individuals with obesity condition having equal metabolic risks, suggesting the presence of a subgroup known as metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO). Obesity is characterized by chronic low-grade inflammation, with C-reactive Protein (CRP) serving as a key inflammatory marker. Research on high-sensitivity CRP (hs-CRP) levels across different obesity categories, especially MHO and MUHO, remains limited.

Aim: This study aims to compare hs-CRP levels across various levels of obesity, particularly in MHO and MUHO individuals.

Methods: This analytical cross-sectional study included subjects aged 18-60 from Denpasar with a BMI over 25 kg/m2. Subjects with chronic or acute inflammatory conditions were excluded. Comparative tests were utilized for analysis.

Results: The study comprised 40 men and 20 women with an average age of 35.6 years. Of these, 35% were classified as MHO and 65% as MUHO. The analysis revealed no significant difference in hs-CRP levels between the MHO and MUHO groups (p = 0.108), likely due to similar age and BMI distributions resulting in comparable levels of inflammation.

Conclusion: The analysis demonstrated no significant variation in hs-CRP levels between MHO and MUHO groups.

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Author Biographies

I Made Pande Dwipayana, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
I Made Siswadi Semadi, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
Ida Bagus Aditya Nugraha, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
Wira Gotera, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
Made Ratna Saraswati, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
Anak Agung Gede Budhiarta, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar
Ketut Suastika, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar

Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/ Prof. dr. I Goesti Ngoerah Gde Ngoerah Hospital Denpasar

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