The effect of probiotics on inflammatory bowel disease Remission and relaps rate: A systematic review and meta-analysis

Authors

  • Louis Edwin Wirya Department of Internal Medicine Siloam Hospitals Kebon Jeruk, Jakarta
  • Heinz Purwadi Gunawan Schoeck Department of Internal Medicine Prof. Dr. IGNG Ngoerah Hospitals, Denpasar ; Division of Gastroenterohepatologi Siloam Hospitals Kebon Jeruk, Jakarta
  • Epistel Pangujian Simatupang Department of Internal Medicine Siloam Hospitals Kebon Jeruk, Jakarta

DOI:

https://doi.org/10.36216/jpd.v8i1.240

Keywords:

Probiotic, Inflammatory Bowel Disease , Remission, Relapse

Abstract

Introduction: Dysbiosis is believed to play a role in the pathogenesis of Inflammatory Bowel Disease (IBD). Therefore, there is a hope that giving probiotics can be an addition to standard IBD treatment. This study aims to examine the efficacy of probiotics on the remission and relapse rates of IBD and its safety profile.

Methods: The authors collected studies from PubMed, Scopus, Embase, Cochrane, and Google Scholar. Inclusion criteria included all randomized controlled trials that compared groups of adult IBD patients (>18 years) who received probiotics and placebo on their standard treatment.

Results: Twenty-four studies met the inclusion criteria with a total sample of 2,233. The mean age of the sample was 39.1 ± 12.4 years in the probiotic group and 38.2 ± 12.3 years in the placebo group. The remission rate in the probiotic group was higher than placebo (OR 1.58, 95% CI 1.28-1.95, p<0.0001). Moreover, the relapse rate in the probiotic group was significantly lower than in the placebo group (OR 0.70 CI 95% 0.53-0.93, p=0.01). There was no significant difference in the incidence of adverse events in the probiotic group compared to placebo (RR 1.04, CI 95% 0.85-1.29, p=0.68). Multistrain probiotics increased the remission rate(OR 2.68, CI 95% 1.88 -3.83, p=<0.00001). Meanwhile, only Bifidobacterium sp. significantly reduced the relapse rate (OR 0.07, p=0.002).

Conclusion: Probiotics can significantly ameliorate the remission rate and reduce the relapse rate in IBD patients. Giving probiotics that contain particular strains can increase the remission rate and reduce the relapse rate in IBD.

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Author Biographies

  • Louis Edwin Wirya, Department of Internal Medicine Siloam Hospitals Kebon Jeruk, Jakarta

    Department of Internal Medicine Siloam Hospitals Kebon Jeruk, Jakarta

  • Heinz Purwadi Gunawan Schoeck, Department of Internal Medicine Prof. Dr. IGNG Ngoerah Hospitals, Denpasar ; Division of Gastroenterohepatologi Siloam Hospitals Kebon Jeruk, Jakarta

    Department of Internal Medicine Prof. Dr. IGNG Ngoerah Hospitals, Denpasar ;

    Division of Gastroenterohepatologi Siloam Hospitals Kebon Jeruk, Jakarta

  • Epistel Pangujian Simatupang, Department of Internal Medicine Siloam Hospitals Kebon Jeruk, Jakarta

    Department of Internal Medicine Siloam Hospitals Kebon Jeruk, Jakarta

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Published

2024-05-05

How to Cite

1.
The effect of probiotics on inflammatory bowel disease Remission and relaps rate: A systematic review and meta-analysis. Udayana In. Med. [Internet]. 2024 May 5 [cited 2024 Jul. 16];8(1):12-8. Available from: https://www.jpdunud.org/index.php/JPD/article/view/240

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